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(DOWNLOAD) "Blood-Brain Barrier in Drug Discovery" by Li Di & Edward H. Kerns * eBook PDF Kindle ePub Free

Blood-Brain Barrier in Drug Discovery

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eBook details

  • Title: Blood-Brain Barrier in Drug Discovery
  • Author : Li Di & Edward H. Kerns
  • Release Date : January 29, 2014
  • Genre: Pharmacology & Toxicology,Books,Professional & Technical,Medical,
  • Pages : * pages
  • Size : 27991 KB

Description

Focused on central nervous system (CNS) drug discovery efforts, this book educates drug researchers about the blood-brain barrier (BBB) so they can affect important improvements in one of the most significant – and most challenging – areas of drug discovery.

• Written by world experts to provide practical solutions to increase brain penetration or minimize CNS side-effects
• Reviews state-of-the-art in silico, in vitro, and in vivo tools to assess brain penetration and advanced CNS drug delivery strategies
• Covers BBB physiology, medicinal chemistry design principles, free drug hypothesis for the BBB, and transport mechanisms including passive diffusion, uptake/efflux transporters, and receptor-mediated processes
• Highlights the advances in modelling BBB pharmacokinetics and dynamics relationships (PK/PD) and physiologically-based pharmacokinetics (PBPK)
• Discusses case studies of successful CNS and non-CNS drugs, lessons learned and paths to the market


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